Composition

Each ml contains:

Colistin sulphate..........20mg

Indications

Poultry, rabbits, calves, lambs: infections caused by sensitive germs.

Dosage and Administration

Oral, in drinking water

Poultry: 750000IU of colistin Kg/day corresponding to 0.25 ml of colistin 210 M.C.I. per liter of drinking water for 3 days.

Other species: 50000 IU of colistin kg/12h corresponding to 0.25 ml of colistin 210 M.C.I. twice a day for 3 days with drinking water or milking feed

Side Effect and Contraindication

The main toxicities described with intravenous treatment are nephrotoxicity (damage to the kidneys) and neurotoxicity (damage to the nerves), but this may reflect the very high doses given, which are much higher than the doses currently recommended by any manufacturer and for which no adjustment was made for renal disease. Neuro- and nephrotoxic effects appear to be transient and subside on discontinuation of therapy or reduction in dose.

At a dose of 160 mg colistin IV every eight hours, very little nephrotoxicity is seen. Indeed, colistin appears to have less toxicity than the aminoglycosides that subsequently replaced it and colistin has been used for extended periods of up to six months with no ill effects.

The main toxicity described with aerosolised treatment is bronchospasm, which can be treated or prevented with the use of beta2-agonists such as salbutamol or following a desensitisation protocol.

Withdrawal Time

Meat and offal: 7 days

Storage and Expired Time

Tightly sealed and store in a dry place below 25°C, avoid lights.

2 years

Packing

1000ml