Trade Name: BULFLOR
Contains per ml:
Florfenicol 300 mg.
Excipients ad 1 ml.
Florfenicol is a synthetic broad-spectrum antibiotic effective against most Gram-positive and Gram-negative bacteria isolated from domestic animals. Florfenicol acts by inhibiting protein synthesis at the ribosomal level and
is bacteriostatic. Laboratory tests have shown that florfenicol is active against the most commonly isolated bacterial pathogens involved in bovine respiratory disease which include Mannheimia haemolytica, Pasteurella multocida,
Histophilus somni and Arcanobacterium pyogenes, and against the bacterial pathogens most commonly isolated in respiratory diseases in pigs, including Actinobacillus pleuropneumoniae and Pasteurella multocida.
Introflor-300 is indicated for preventive and therapeutic treatment of respiratory tract infections in cattle due to Mannheimia haemolytica, Pasteurella multocida and Histophilus somni. The presence of the disease in the herd should be established before preventive treatment. It is additionally indicated for treatment of acute outbreaks of respiratory disease in pigs caused by strains of Actinobacillus pleuropneumoniae and Pasteurella multocida susceptible to florfenicol.
Not for use in cattle producing milk for human consumption.
Not to be used in adult bulls or boars intended for breeding purposes.
Do not administer in cases of previous allergic reactions to florfenicol.
In cattle, a decrease in food consumption and transient softening of the faeces may occur during the treatment period. The treated animals recover quickly and completely upon termination of treatment. Administration of the product by the intramuscular and subcutaneous routes may cause inflammatory lesions at injection site which persist for 14 days.
In swine, commonly observed adverse effects are transient diarrhoea and/or peri-anal and rectal erythema/oedema which may affect 50% of the animals. These effects can be observed for one week. Transient swelling lasting up to 5 days may be observed at the site of injection. Inflammatory lesions at the injection site may be seen up to 28 days.
For subcutaneous or intramuscular injection.
Treatment (IM) : 1 ml per 15 kg body weight, twice at a 48-h interval.
Treatment (SC) : 2 ml per 15 kg body weight, administered once.
Prevention (SC) : 2 ml per 15 kg body weight, administered once.
The injection should only be given in the neck. The dose should not exceed 10 ml per injection site.
Swine : 1 ml per 20 kg body weight (IM), twice at a 48-hour interval.
The injection should only be given in the neck. The dose should not exceed 3 ml per injection site.
It is recommended to treat animals in the early stages of disease and to evaluate the response to treatment within 48 hours after the second injection. If clinical signs of respiratory disease persist 48 hours after the last injection, treatment should be changed using another formulation or another antibiotic and continued until clinical signs have resolved. Note: Introflor-300 is not for use in cattle producing milk for human consumption.
- For meat:
Cattle : 30 days (IM route).
44 days (SC route).
Swine : 18 days.
Vial of 100 ml.
Hello, Acalculous cholecystitis is a gallbladder inflammation without gallstones. Patients can have signs of fever, jaundice, right upper quadrant mass and pain, and Murphy’s sign, which is gallbladder pain induced by your hand when you palpate the gallbladder at the same time as the patient inhale. Patients are usually very ill due to complications of gallbladder inflammation, like Gallbladder necrosis, gangrene, and perforation, that can lead to peritonitis, sepsis, and shock.The lab values can show increased amount of Alkaline phosphatase, Aminotransferases, Bilirubin and Leukocytes. The most important test to make is Ultrasonography. Ultrasonography can show that there are no gallstones or sludge; more than 3 mm gallbladder wall thickening, more than 5 cm gallbladder distension, a striated gallbladder, mucosal sloughing, a positive Murphy’s sign induced by the ultrasonography probe, pericholecystic fluid that indicates perforation that can lead to abscess formation, and “Champagne sign” with gas bubbles in gallbladder fundus. If Ultrasonography is not enough for diagnosis, then Cholescintigraphy, a so-called HIDA scan can be used. But it takes hours to perform, so it’s not recommended in critically ill patients in whom a delay in therapy could be deadly. Here we inject Technetium labeled Hepatic IminoDiacetic Acid that is taken up by liver cells and excreted into bile to the gallbladder. If this does not happen, then it’s an indication of acalculous cholecystitis. We can inject Morphine that helps the liver cells to secrete bile into the gallbladder, and thereby makes the diagnosis easier. We treat acalculous cholecystitis with antibiotics and surgery. Before giving antibiotics, we need to take a blood culture. While we wait for the blood culture results, we start a broad-spectrum antibiotic combination, like Ampicillin-Sulbactam, or Piperacillin-Tazobactam, or Ticarcillin-Clavulanate, or Ceftriaxone-Metronidazole. When we get the blood culture results we start to treat the specific microbes that infect the gallbladder, like for example Bacteroides, Escherichia coli, Enterococcus faecalis, Klebsiella, Methicillin-resistant Staphylococcus aureus (MRSA), Pseudomonas, or Proteus species. Then it’s very important to surgically operate as soon as possible. We usually start with a Cholecystostomy. But if we don’t see an improvement within 24 hours after the operation, we start Cholecystectomy immediately. Sometimes, when there is gallbladder necrosis, perforation, or emphysematous cholecystitis, we start with Cholecystectomy right from the beginning. Thank you very much for listening!
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