Synonyms: Identification numbers
CAS number: 70288-86-7 (mixture)
Other numbers: 70161-11-4 (component B1a) 70209-81 (component B1b)
Brand names, Trade names: BULIVER, SANIVER, VIMIVER
Each ml. contains ivermectin 10 mg.
Parasitic diseases are common in animals. Parasites can affect the skin, ears, stomach and intestines, and the internal organs including the heart, lungs and liver. Several drugs have been developed to kill or prevent parasites such as fleas, ticks, mites and worms. Ivermectin and related drugs are among the most effective of these.
Ivermectin is a parasite control drug. Ivermectin causes neurologic damage to the parasite, resulting in paralysis and death. Ivermectin has been used to prevent parasite infections, as with heartworm prevention, and to treat infections, as with ear mites.
Ivermectin is a prescription drug and can only be obtained from a veterinarian or by prescription from a veterinarian.
The injection is mainly applied to treat domestic animal’s diseases of gastrointestinal nematodes, hypoderma bovis, hypoderma lineatum, sheep nose bot, psoroptes ovis, sarcoptes scabiei var. Suis,sarcoptes ovis, fasciola(Liver Fluke), oestrus spp and the like.
Cattle: Ostertagia ostertagi (including inhibited o. ostertagi), o. lyrata, haemonchus placei, trichostrongylus axei, t. colubriformis, cooperia oncophora, c. punctata, c. pectinata, bunostomum phlebotomum, nematodirus helvetianus (adults only), n. spathiger (adults only), oesophagostomum radiatum, dictyocaulus viviparus, fasciola hepatica (adults only), hypoderma bovis, h. lineatum, linognathus vituli, haematopinus eurysternus, solenopotes capillatus, psoroptes ovis (syn. p. communis var. bovis), sarcoptes scabiei var. bovis. Sheep: Oestrus ovis, sarcoptes scabiei, psoregates var ovis, trichostrongylus axei, haemonchus sps., ostertagia sps., trichostrongylus sps., nematodirus sps., cooperia sps., bunostomum sps., strongyloides sps., oesophagastomum sps., chabertia sps., trichuris sps., dictyocaulus sps. Dogs: Sarcoptes scabiei, otodectes cynotis, toxascaris leonina, toxocara caninum / cati, uncinaria stenocephala, ancylostoma caninum, trichuris vulpis,dirifilaria (larval stages)
Usage and administration:
Cattle: 1.0 ml/50 kg body weight.
Sheep: 0.5 ml/25 kg body weight.
Dogs: 0.5 ml /25 kg body weight.
Medication should never be administered without first consulting your veterinarian. The dose for ivermectin varies from species to species and also depends on the intent of treatment. General dosing guidelines follow.
For dogs: Dose is 0.0015 to 0.003 mg per pound (0.003 to 0.006 mg/kg) once a month for heartworm prevention; 0.15 mg per pound (0.3 mg/kg) once, then repeat in 14 days for skin parasites; and 0.1 mg per pound (0.2 mg/kg) once for gastrointestinal parasites.
For cats: Dose is 0.012 mg per pound (0.024 mg/kg) once monthly for heartworm prevention.
The duration of administration depends on the condition being treated, response to the medication and the development of any adverse effects. Be certain to complete the prescription unless specifically directed by your veterinarian. Even if your pet feels better, the entire treatment plan should be completed to prevent relapse or prevent the development of resistance.
Side effect and contraindication:
While generally safe and effective when prescribed by a veterinarian, ivermectin can cause side effects in some animals. Ivermectin should not be used in animals with known hypersensitivity or allergy to the drug. Ivermectin should be used with caution in collie breeds or collie mixed breeds due to potential toxic effects. This is particularly true when using higher doses. Ivermectin should not be used in dogs that are positive for heartworm disease except under strict supervision of a veterinarian. Prior to starting a heartworm prevention containing ivermectin, the dog should be tested for heartworms. Ivermectin generally should be avoided in dogs less than 6 weeks of age. Ivermectin is relatively safe, but overdoses can occur if massive amounts are given or if the drug is given to heartworm positive dogs. Signs of overdose, including stumbling, tremors, blindness, disorientation or weakness, generally occur within 12 hours of overdose.
In heartworm positive dogs, supportive treatment for shock may be required. Ivermectin should be used with caution at high doses, a drug used to treat or prevent flea infestations.
The withdrawal time of 49 days has been established for ivermectin and clorsulon in cattle and sheep for slaughter. A withdrawal period for milk has not been established.
Keep this and all drugs out of the reach of children.
Storage and expired time：
Put in cool, dry and dark place.
Magnesium ascorbyl phosphate, L-ascorbic acid, ascorbyl glucosamine, and ascorbic acid are various forms of vitamin C considered stable and effective antioxidants for skin. The concentrations of these ingredients used in tests were generally high (more than 5%), which is rarely used in cosmetic formulations. Vitamin C can help brighten the skin tone. Latest scientific studies have revealed that vitamin C is also a powerful antioxidant that can avert and probably even reverse the consequences of aging on human skin. Studies have also shown that vitamin C decrease the development of melanin. According to those results vitamin C could have a significant skin lightening properties because melanin is liable for the dark pigmentation of the human skin. Therefore, vitamin C can be utilized to clarify or even change the skin tones, lighten the dark skin blemishes associated with aging or as a whitening skin care beauty product.
There is an increasing awareness that vitamin C has a wide variety of role in human health. New therapeutic uses are being investigated daily, among recent discoveries is that Vitamin C can play important role in the health and beauty of your skin. Vitamin C as ascorbyl form has been tested extensively and reported in journal of American Academy of Dermatology to inhibit the production of the melanin (Melanin is the pigment which give the skin it’s dark color), when Vitamin C inhibit the production of the melanin, a lighter and brighter skin will reveal in just few weeks.
Vitamin C does more than that also, vitamin C is required for collagen synthesis, which declines markedly in aging skin. As we grow older, we suffer diminished micro capillary circulation within our skin, which deprives our skin cells of the supply of vitamin C it needs for youthful collagen synthesis. The topical application of vitamin C in a skin-penetrating medium can dramatically enhance the availability of vitamin C for collagen production. Vitamin C regenerates vitamin E in the skin. An antioxidant like vitamin E can only suppress a limited number of free radicals before it runs out of electrons to donate. Vitamin C regenerates vitamin E and enables vitamin E to provide sustained antioxidant protection in the skin’s elastin fibers. Vitamin C plays a vital role in skin repair. When your skin is injured, its Vitamin C content is used up rapidly in the scavenging of free radicals, and in synthesizing collagen to speed healing.
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