Contains per ml.:
Iron (as iron dextran) 100 mg.
Vitamin B12, cyanocobalamin 100 μg.
Solvents ad. 1 ml.
Iron dextran is used for prophylaxis and treatment of by iron deficiency caused anaemia in piglets and calves. Parenteral administration of iron has the advantage that the necessary amount of iron can be administered in one single dosage. Cyanocobalamin is used for prophylaxis and treatment of by cyanocobalamin deficiency caused anaemia.
Prophylaxis and treatment of anaemia in calves and piglets.
Administration to animals with vitamin E?deficiency.
Administration to animals with diarrhoea.
Administration in combination with tetracyclines, because of the interaction of iron with tetracyclines.
Muscle tissue is coloured temporarily by this preparation.
Leaking of injection fluid can cause a persistent discoloration of skin.
For intramuscular or subcutaneous administration:
Calves : 4 – 8 ml. subcutaneous, in the first week after birth.
Piglets : 2 ml. intramuscular, 3 days after birth.
Keep out of reach of children.
Vial of 100 ml.
Pathogenesis of inflammation
P. acnes is found in low numbers on normal skin and is probably not
infectious. The bacteria may be the primary factor in the production of
inflammatory acne. The mixture of abnormally desquamated cells and
excessive amounts of sebum in the microcomedo provides a lipid rich
environment for bacteria to thrive. They produce neutrophil chemotactic
factors and stimulate neutrophils to release lysosomal enzymes. These
proinflammatory mediators attack the microcomedo follicular wall and
contribute to the formation of inflammatory lesions. Acne improves
when the P. acnes numbers are reduced. P. acnes is sensitive to many
antibiotics. The problem is to deliver antibiotics into the lipid-rich
environment of the sebaceous follicles where the organism is
proliferating. Topical and oral antibiotics are used alone or in
combination with topical retinoids. Retinoids disrupt the microcomedo.
Benzoyl peroxide is an effective non-specific antimicrobial agent. It
penetrates sebum and suppresses the growth of P. acnes more effectively than topical clindamycin and erythromycin. It has only a weak effect on inflammation and little comedolytic activity. It does not stimulate bacterial resistance like erythromycin and clindamycin. Product formulations include gels, creams, lotions, cleansers and bar soaps. It is available in available in 2.5, 4, 5, 6, 8, 9 and 10 percent
formulations. Sulfoxyl strong and Sulfoxyl regular are 10 and 5
percent formulations of benzoyl peroxide that contain sulfur. They are
antibacterial and keratolytic and can be very effective for patients
with pustular acne and oily skin.
PB causes concentration-dependent irritation, erythema and dryness. It
has the potential to cause allergic contact dermatitis. Suspect this
side effect when patients complain of the acute onset of erythema and
itching at a higher intensity that would be expected from just
irritation from the base. Benzoyl peroxide can bleach clothing.
Benzoyl peroxide is available as a 5 percent gel in combination with
erythromycin called Benzamycin. There are two benzoyl peroxide
clindamycin combination products. Benzaclin is available in a jar.
Duac is available in a tube. These combination products result in
greater reductions in inflammatory lesions and comedones at 16 weeks when compared to monotherapy with clindamycin. BP helps to reduce the emergence to resistant variants of P. acnes.
Clindamycin is effective as monotheryapy for short periods of
treatment. Products include solution, lotions, gels and pledgets. It
can be especially effective when used as combination therapy with
retinoids such as tretinoin, tazarotene, and adapalene. If use for
longer than 3 months is required than switch to a combination benzoyl
peroxide/clindamycin product to avoid the problems of bacterial
resistance to clindamycin.