Oxytetracycline Dihydrate 300mg/ml
Flunixin, as Flunixin Meglumine 20mg/ml
Sodium Formaldehyde Sulphoxylate is also included as achemical preservative.
Oxytetracycline is a member of the tetracycline family of broadspectrum antibiotics that inhibit protein synthesis in susceptible microorganisms.
Flunixin meglumine is a relatively potent non-narcotic, non-steroidal analgesic with antiinflammatory, anti-endotoxic and anti-pyretic properties.
This Injection is specifically formulated to provide initial anti-inflammatory activity for 24-36 hours and sustained anti-bacterial activity for 5-6 days following a single administration.
This injection is indicated primarily for the treatment of bovine respiratory disease associated with Mannheimia haemolytica,where an antiinflammatory and antipyretic effect is required. In addition a wide range of organisms including Pasteurellaspp, Arcanobacterium pyogenes, Staphylococcus aureus and certain mycoplasmas are known to be sensitive in vitro to oxytetracycline.
This injection may, therefore, be of use in the treatment of disease in cattle caused by such organisms where both antiinflammatory and antipyretic effect is required.
Dosage and Administration:
For deep intramuscular injection to cattle.
The recommended dosage is 1ml per 10kg bodyweight (equivalent to 30mg/kg oxytetracycline and 2mg/kg flunixin) on a single occasion.
Maximum volume per injection site: 15ml. If concurrent treatment is administered, use a separate injection site.
Animals must not be slaughtered for human consumption during treatment.
Cattle may be slaughtered for human consumption only after 35 days from the last treatment.
Not for use in cattle producing milk for human consumption.
Use is contraindicated in animals suffering from cardiac, hepatic or renal disease, where there is a possibility of gastrointestinal ulceration or bleeding or where there is hyper sensitivity to the product.
Avoid use in dehydrated, hypovolaemic or hypotensive animals as there is a potential risk of increased renal toxicity.
Do not administer other NSAIDs concurrently or within 24hours of each other.
Concurrent use of potentially nephrotoxic drugs should beavoided. Do not exceed the stated dose or duration of treatment.
If you notice any serious effects or other effects not mentioned in this leaflet, please inform your veterinary surgeon.
Avoid intra-arterial injection.
Use in any animals less than 6 weeks of age or in aged animals may involve additional risk. If such use cannot be avoided, animals may require a reduced dosage and careful clinical management.
Some NSAIDs may be highly bound to plasma proteins and compete with other highly bound drugs which can lead totoxic effects.
Although Oxytetracycillin and Flunixin injection is well tolerated, occasionally a local reaction of a transient nature may be observed. The use of tetracyclines during the period of tooth and bone development, including late pregnancy, may lead todiscolouration.
If concurrent treatment is administered, use a separate injection site.
It is preferable that prostaglandin-inhibiting drugs are not administrated to animals undergoing general anaesthesiauntil fully recovered.
Avoid eye contact and direct contact with skin.
To avoid possible sensitisation reactions, avoid contact with skin.
Gloves should be worn during application.
Wash hands after use.
In the case of accidental contact with eyes, rinse immediately with plenty of water and seek medical advice. The product may cause reactions in sensitive individuals. If you have known hypersensitivity for non-steroidal anti-inflammatory products, do not handle the product. Reactions may be serious.
Avoid accidental self-injection.
Dispose of any unused product and empty containers in accordance with guidance from your local waste regulation authority.
Store upright only. Keep the container in the outer carton.
Do not store above 25℃.
Following withdrawal of the first dose, use the product within 28 days.
When the container is broached for the first time, using the inuse shelflife which is specified on the package, insert, the date on which any product remaining in the container should be discarded should be worked out. This discard date should be written in the space provided on the label.
To be supplied only on Veterinary Prescription.
Not all pack sizes may be marketed.
Clinically beneficial anti-inflammatory activity has been demonstrated following the single administration of flunixin in this injection. However, additional NSAID therapy may be administered after 24 hours if desired. Following intramuscular injection of at there commended dose rate effective oxytetracycline blood levels persist for 5-6 days.
For Animal Treatment Only.
Keep out of reach and sight of Children.
Hello, Acalculous cholecystitis is a gallbladder inflammation without gallstones. Patients can have signs of fever, jaundice, right upper quadrant mass and pain, and Murphy’s sign, which is gallbladder pain induced by your hand when you palpate the gallbladder at the same time as the patient inhale. Patients are usually very ill due to complications of gallbladder inflammation, like Gallbladder necrosis, gangrene, and perforation, that can lead to peritonitis, sepsis, and shock.The lab values can show increased amount of Alkaline phosphatase, Aminotransferases, Bilirubin and Leukocytes. The most important test to make is Ultrasonography. Ultrasonography can show that there are no gallstones or sludge; more than 3 mm gallbladder wall thickening, more than 5 cm gallbladder distension, a striated gallbladder, mucosal sloughing, a positive Murphy’s sign induced by the ultrasonography probe, pericholecystic fluid that indicates perforation that can lead to abscess formation, and “Champagne sign” with gas bubbles in gallbladder fundus. If Ultrasonography is not enough for diagnosis, then Cholescintigraphy, a so-called HIDA scan can be used. But it takes hours to perform, so it’s not recommended in critically ill patients in whom a delay in therapy could be deadly. Here we inject Technetium labeled Hepatic IminoDiacetic Acid that is taken up by liver cells and excreted into bile to the gallbladder. If this does not happen, then it’s an indication of acalculous cholecystitis. We can inject Morphine that helps the liver cells to secrete bile into the gallbladder, and thereby makes the diagnosis easier. We treat acalculous cholecystitis with antibiotics and surgery. Before giving antibiotics, we need to take a blood culture. While we wait for the blood culture results, we start a broad-spectrum antibiotic combination, like Ampicillin-Sulbactam, or Piperacillin-Tazobactam, or Ticarcillin-Clavulanate, or Ceftriaxone-Metronidazole. When we get the blood culture results we start to treat the specific microbes that infect the gallbladder, like for example Bacteroides, Escherichia coli, Enterococcus faecalis, Klebsiella, Methicillin-resistant Staphylococcus aureus (MRSA), Pseudomonas, or Proteus species. Then it’s very important to surgically operate as soon as possible. We usually start with a Cholecystostomy. But if we don’t see an improvement within 24 hours after the operation, we start Cholecystectomy immediately. Sometimes, when there is gallbladder necrosis, perforation, or emphysematous cholecystitis, we start with Cholecystectomy right from the beginning. Thank you very much for listening!
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