It is a reddish injectable solution.
Generic name: Nitroxynil Injection 34%.
Brand Name: Buxynil 34
Mol Weight:290.02 CAS No:1689-89-0
Buxynil 34 is nitrate derivative from benzene compounds and presents a flukicide effect and is commonly used and the one with best spectrum from all the nitrate derivative trematocides. The mechanism of action corresponds to a respiratory metabolism interference of the helminth, blocking the energy production by mitochondrial oxidative phosphorylation. Buxynil 34 impedes to use the oxide-reduction reactions for adenosine triphosphate (ATP) production. After the use of all its energetic reserves the parasites die due to starvation.
Buxynil 34 also causes the scolex detachment of the intestinal mucosa and the proximal proglottid of the cestode. Studies realized with Buxynil 34 demonstrates that effective blood levels are reached after 5 hours of the drug's administration and with maximum peaks after 12 hours, with an activity threshold during 30 days that maximizes its antiparasitic action.
There can be noted that it is associated strongly to the plasmatic proteins favoring its distribution to the tissues and its slow elimination of the organism. The biotransformation occurs in the gastrointestinal tract and liver. The Buxynil 34 and its metabolites are eliminated by faeces through the bile route.
It is suggested that it acts inhibiting the oxidative phosphorylation. It is possible to confirm its effects over Fasciola gigantica in laboratory conditions, after adding 20 mg/ml in vitro, which induces the immediate stop of the muscular contractions, making think that acts as neuromuscular blocker, due to this the parasite dies paralyzed and with energy deficiency.
Buxynil 34 is used by parenteral route because in the rumen would suffer an efficiency reduction; the maximum plasmatic levels are acquired between 30 and 60 minutes and the mean life is 8 days; the excretion occurs through urine during 30 days approximately.
Buxynil 34 is indicated for control of Fasciolosis (larval and adult stage) caused by Fasciola hepatica and F. gigantica; gastrointestinal parasitism caused by Haemonchus spp., Bunostomum spp., Oesophagostomum spp., Oestrus spp. in cattle, sheep, goats and camel, as well as Ancylostoma spp. and Uncinaria spp.in dogs.
Buxynil 34 is developed and tested for its use in cattle, sheep, goats, camel and dogs.
DOSAGE AND ADMINISTRATION
Subcutaneous route only.
The Standard dosage is 10mg per 1 kg bodyweight (=1.5 ml of Buxynil 34/50kg b.w.).
Cattle, Sheep, Goat, Camel and Dogs:
1ml every 50kg of body weight against Fasciola hepatica and F.gigantica.
1.5 ml every 50 kg of body weight against Haemochus contortus, Oesophagostomum spp., Bunostomum spp., Ancylostoma caninum and Uncinatia spp.
2.0 ml every 50 kg of body weight in cases of acute severe Fasciolosis and Oestrosis in sheep (Oestrus ovis).
A slight swelling may appear at the site of inoculation, which will disappear in a few days.
PRECAUTIONS AND WARNINGS
Only dose cows on dry period.
Do not mix in the same syringe or container with any other substance different to the product.
The containers and any residue of product should be eliminated in a safe way (burial or incineration).
The use on other species than authorized is not recommended.
It can be used at any stage of pregnancy (however, in the last third, the product must be managed very carefully under professional supervision); it does not affect fertility, gestation nor fetus formation, and it does not affect the reproductive performance of stallions.
In case of intoxication, keep the patient in a cold place and administer dextrose by endovenous route.
In case of ingestion, wash mouth and request help to the veterinarian.
Be careful of auto inject accidentally. Seek medical attention in case of accidental injection.
Meat: 30 days. Milk: 5 days. Dose only cows on dry period.
Buxynil 34 is available in bottle of 100ml
Store in a cool, dry and dark place.
Hello, Acalculous cholecystitis is a gallbladder inflammation without gallstones. Patients can have signs of fever, jaundice, right upper quadrant mass and pain, and Murphy’s sign, which is gallbladder pain induced by your hand when you palpate the gallbladder at the same time as the patient inhale. Patients are usually very ill due to complications of gallbladder inflammation, like Gallbladder necrosis, gangrene, and perforation, that can lead to peritonitis, sepsis, and shock.The lab values can show increased amount of Alkaline phosphatase, Aminotransferases, Bilirubin and Leukocytes. The most important test to make is Ultrasonography. Ultrasonography can show that there are no gallstones or sludge; more than 3 mm gallbladder wall thickening, more than 5 cm gallbladder distension, a striated gallbladder, mucosal sloughing, a positive Murphy’s sign induced by the ultrasonography probe, pericholecystic fluid that indicates perforation that can lead to abscess formation, and “Champagne sign” with gas bubbles in gallbladder fundus. If Ultrasonography is not enough for diagnosis, then Cholescintigraphy, a so-called HIDA scan can be used. But it takes hours to perform, so it’s not recommended in critically ill patients in whom a delay in therapy could be deadly. Here we inject Technetium labeled Hepatic IminoDiacetic Acid that is taken up by liver cells and excreted into bile to the gallbladder. If this does not happen, then it’s an indication of acalculous cholecystitis. We can inject Morphine that helps the liver cells to secrete bile into the gallbladder, and thereby makes the diagnosis easier. We treat acalculous cholecystitis with antibiotics and surgery. Before giving antibiotics, we need to take a blood culture. While we wait for the blood culture results, we start a broad-spectrum antibiotic combination, like Ampicillin-Sulbactam, or Piperacillin-Tazobactam, or Ticarcillin-Clavulanate, or Ceftriaxone-Metronidazole. When we get the blood culture results we start to treat the specific microbes that infect the gallbladder, like for example Bacteroides, Escherichia coli, Enterococcus faecalis, Klebsiella, Methicillin-resistant Staphylococcus aureus (MRSA), Pseudomonas, or Proteus species. Then it’s very important to surgically operate as soon as possible. We usually start with a Cholecystostomy. But if we don’t see an improvement within 24 hours after the operation, we start Cholecystectomy immediately. Sometimes, when there is gallbladder necrosis, perforation, or emphysematous cholecystitis, we start with Cholecystectomy right from the beginning. Thank you very much for listening!