Contains per ml::
Oxytetracycline base (as dihydrate) 300 mg.
Excipients ad 1 ml.
Oxytetracycline belongs to the group of tetracyclines and acts bacteriostatically against many Gram-positive and Gram-negative bacteria like Bordetella, Actinomyces, Erysipelothrix, Pasteurella, Staphylococcus and Streptococcus spp. Certain mycoplasma, rickettsiae, protozoa and chlamydia are also sensitive to oxytetracycline. Its mode of action is based on inhibition of bacterial protein synthesis by reversibly binding to 30S ribosomal subunits of susceptible organisms. Tetracyclines are widely distributed in the body, including kidney, lung, muscle, bile, saliva and urine. Oxytetracycline is eliminated unchanged primarily via glomerular filtration. Depending on the dose administered, one injection provides a duration of activity of 3 to 6 days.
Treatment and control of a wide range of common systemic, respiratory, urinary and local infections in cattle, sheep and swine caused by, or associated with, oxytetracycline sensitive organisms such as Bordetella bronchiseptica, Actinomyces pyogenes, Erysipelothrix rhusiopathiae, Pasteurella, Staphylococcus and Streptococcus spp., and certain mycoplasma, rickettsiae, protozoa and chlamydia. Specific indications include pasteurellosis, pneumonia, atrophic rhinitis, erysipelas, joint ill, navel ill, supportive therapy in bovine mastitis, ovine keratoconjunctivitis (pink eye) and enzootic abortion in sheep.
Hypersensitivity to tetracyclines.
Administration to animals with a seriously impaired renal and/or hepatic function.
Concurrent administration of bactericidal antibiotics such as penicillins and cephalosporins.
After intramuscular administration local reactions of a transient nature, characterised by swelling and/or hardness, may occur.
Use of the product during the period of tooth and bone development, including late pregnancy, can lead to discoloration.
Overdoses may result in nephrotoxicity.
For deep intramuscular administration.
Administer Limoxin-300 LA at the standard dose of 20 mg/kg for 3 to 4 days duration of activity for the treatment and control of conditions caused by organisms sensitive to oxytetracycline. Administer at the high dose of 30 mg/kg for the treatment and control of respiratory infections in cattle, sheep and swine.
1 ml per 15 kg body weight (20 mg/kg).
1 ml per 10 kg body weight (30 mg/kg).
Do not inject more than 10 ml in cattle and swine or more than 5 ml in sheep per injection site. Piglets should not receive more than 0.2 ml (1 day old), 0.3 ml (7 days old), 0.4 ml (14 days old) or 0.5 ml (21 days old) per injection site. Piglets older than 21 days old should receive the high dose (1 ml/10 kg; 30 mg/kg).
- For meat (standard dose):
Cattle and sheep : 28 days.
Swine : 14 days.
- For meat (high dose):
Cattle : 35 days.
Sheep and swine: 28 days.
- For milk:
Cattle : 10 days.
Sheep : 8 days.
Vial of 50 and 100 ml.
Hello, Acalculous cholecystitis is a gallbladder inflammation without gallstones. Patients can have signs of fever, jaundice, right upper quadrant mass and pain, and Murphy’s sign, which is gallbladder pain induced by your hand when you palpate the gallbladder at the same time as the patient inhale. Patients are usually very ill due to complications of gallbladder inflammation, like Gallbladder necrosis, gangrene, and perforation, that can lead to peritonitis, sepsis, and shock.The lab values can show increased amount of Alkaline phosphatase, Aminotransferases, Bilirubin and Leukocytes. The most important test to make is Ultrasonography. Ultrasonography can show that there are no gallstones or sludge; more than 3 mm gallbladder wall thickening, more than 5 cm gallbladder distension, a striated gallbladder, mucosal sloughing, a positive Murphy’s sign induced by the ultrasonography probe, pericholecystic fluid that indicates perforation that can lead to abscess formation, and “Champagne sign” with gas bubbles in gallbladder fundus. If Ultrasonography is not enough for diagnosis, then Cholescintigraphy, a so-called HIDA scan can be used. But it takes hours to perform, so it’s not recommended in critically ill patients in whom a delay in therapy could be deadly. Here we inject Technetium labeled Hepatic IminoDiacetic Acid that is taken up by liver cells and excreted into bile to the gallbladder. If this does not happen, then it’s an indication of acalculous cholecystitis. We can inject Morphine that helps the liver cells to secrete bile into the gallbladder, and thereby makes the diagnosis easier. We treat acalculous cholecystitis with antibiotics and surgery. Before giving antibiotics, we need to take a blood culture. While we wait for the blood culture results, we start a broad-spectrum antibiotic combination, like Ampicillin-Sulbactam, or Piperacillin-Tazobactam, or Ticarcillin-Clavulanate, or Ceftriaxone-Metronidazole. When we get the blood culture results we start to treat the specific microbes that infect the gallbladder, like for example Bacteroides, Escherichia coli, Enterococcus faecalis, Klebsiella, Methicillin-resistant Staphylococcus aureus (MRSA), Pseudomonas, or Proteus species. Then it’s very important to surgically operate as soon as possible. We usually start with a Cholecystostomy. But if we don’t see an improvement within 24 hours after the operation, we start Cholecystectomy immediately. Sometimes, when there is gallbladder necrosis, perforation, or emphysematous cholecystitis, we start with Cholecystectomy right from the beginning. Thank you very much for listening!