Each ml contains:
Diminazene Aceturate —-70 mg
Phenazone BP ————-37.5 mg
Water for Injection BP—-qs
DIMINAZENE injection is indicated for the treatment of Babesiosis, Trypanosomiasis, Theileriosis,
mixed haemoprotozoal infections and Pyrexia of Unknown Origin (PUO) in livestock.
DOSAGE AND ADMINISTRATION:
Babesiosis and Trypanosomiasis at the dose rate of 5-10 ml per 100 kg body weight.
Theileriosis at the dose rate of 5-10 ml per 100 kg body weight along with antibiotic (3-4 antibiotic injections in alternate days).
Mixed infections / Pyrexia of unknown origin at the dose rate of 5 ml per 100 kg body weight.
The total doses should not exceed 56 ml of DIMINAZENE injectable solution at a time per animal,
preferably by deep intramuscular route at multiple sites.
Meat: 21 days; Milk: 3 days
50 ml and 100 ml
Shivam Pharma created this video with the YouTube Slideshow Creator
Uptake of DNA during transformation | natural competence
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In molecular biology transformation is genetic alteration of a cell resulting from the direct uptake, incorporation and expression of exogenous genetic material (exogenous DNA) from its surroundings and taken up through the cell membrane(s). Transformation occurs naturally in some species of bacteria, but it can also be effected by artificial means in other cells. For transformation to happen, bacteria must be in a state of competence, which might occur as a time-limited response to environmental conditions such as starvation and cell density. Transformation is one of three processes by which exogenous genetic material may be introduced into a bacterial cell, the other two being conjugation (transfer of genetic material between two bacterial cells in direct contact) and transduction (injection of foreign DNA by a bacteriophage virus into the host bacterium). “Transformation” may also be used to describe the insertion of new genetic material into nonbacterial cells, including animal and plant cells; however, because “transformation” has a special meaning in relation to animal cells, indicating progression to a cancerous state, the term should be avoided for animal cells when describing introduction of exogenous genetic material. Introduction of foreign DNA into eukaryotic cells is often called “transfection”.
Natural transformation is a bacterial adaptation for DNA transfer that depends on the expression of numerous bacterial genes whose products appear to be designed to carry out this process. In general, transformation is a complex, energy requiring developmental process. In order for a bacterium to bind, take up and recombine exogenous DNA into its chromosome it must become competent, that is, enter a special physiological state. Competence development in Bacillus subtilis requires expression of about 40 genes. The DNA integrated into the host chromosome is usually (but with rare exceptions) derived from another bacterium of the same species, and is thus homologous to the resident chromosome.
In B. subtilis the length of the transferred DNA is greater than 1271 kb (more than 1 million bases). The length transferred is likely double stranded DNA and is often more than a third of the total chromosome length of 4215 kb. It appears that about 7-9% of the recipient cells take up an entire chromosome.
The capacity for natural transformation appears to occur in a number of prokaryotes, and thus far 67 prokaryotic species (in seven different phyla) are known to undergo this process.
Competence for transformation is typically induced by high cell density and/or nutritional limitation, conditions associated with the stationary phase of bacterial growth. Transformation in Haemophilus influenzae occurs most efficiently at the end of exponential growth as bacterial growth approaches stationary phase.  Transformation in Streptococcus mutans, as well as in many other streptococci, occurs at high cell density and is associated with biofilm formation.  Competence in B. subtilis is induced toward the end of logarithmic growth, especially under conditions of amino acid limitation.  Source of the article published in description is Wikipedia. I am sharing their material. © by original content developers of Wikipedia.
Link- https://en.wikipedia.org/wiki/Main_Page Material source: Molecular Genetics of Bacteria
Larry Snyder (Author), Joseph E. Peters (Author), Tina M. Henkin (Author), Wendy Champness (Author)