Contains per ml::
Oxytetracycline base (as dihydrate) 300 mg.
Excipients ad 1 ml.
Oxytetracycline belongs to the group of tetracyclines and acts bacteriostatically against many Gram-positive and Gram-negative bacteria like Bordetella, Actinomyces, Erysipelothrix, Pasteurella, Staphylococcus and Streptococcus spp. Certain mycoplasma, rickettsiae, protozoa and chlamydia are also sensitive to oxytetracycline. Its mode of action is based on inhibition of bacterial protein synthesis by reversibly binding to 30S ribosomal subunits of susceptible organisms. Tetracyclines are widely distributed in the body, including kidney, lung, muscle, bile, saliva and urine. Oxytetracycline is eliminated unchanged primarily via glomerular filtration. Depending on the dose administered, one injection provides a duration of activity of 3 to 6 days.
Treatment and control of a wide range of common systemic, respiratory, urinary and local infections in cattle, sheep and swine caused by, or associated with, oxytetracycline sensitive organisms such as Bordetella bronchiseptica, Actinomyces pyogenes, Erysipelothrix rhusiopathiae, Pasteurella, Staphylococcus and Streptococcus spp., and certain mycoplasma, rickettsiae, protozoa and chlamydia. Specific indications include pasteurellosis, pneumonia, atrophic rhinitis, erysipelas, joint ill, navel ill, supportive therapy in bovine mastitis, ovine keratoconjunctivitis (pink eye) and enzootic abortion in sheep.
Hypersensitivity to tetracyclines.
Administration to animals with a seriously impaired renal and/or hepatic function.
Concurrent administration of bactericidal antibiotics such as penicillins and cephalosporins.
After intramuscular administration local reactions of a transient nature, characterised by swelling and/or hardness, may occur.
Use of the product during the period of tooth and bone development, including late pregnancy, can lead to discoloration.
Overdoses may result in nephrotoxicity.
For deep intramuscular administration.
Administer Limoxin-300 LA at the standard dose of 20 mg/kg for 3 to 4 days duration of activity for the treatment and control of conditions caused by organisms sensitive to oxytetracycline. Administer at the high dose of 30 mg/kg for the treatment and control of respiratory infections in cattle, sheep and swine.
1 ml per 15 kg body weight (20 mg/kg).
1 ml per 10 kg body weight (30 mg/kg).
Do not inject more than 10 ml in cattle and swine or more than 5 ml in sheep per injection site. Piglets should not receive more than 0.2 ml (1 day old), 0.3 ml (7 days old), 0.4 ml (14 days old) or 0.5 ml (21 days old) per injection site. Piglets older than 21 days old should receive the high dose (1 ml/10 kg; 30 mg/kg).
- For meat (standard dose):
Cattle and sheep : 28 days.
Swine : 14 days.
- For meat (high dose):
Cattle : 35 days.
Sheep and swine: 28 days.
- For milk:
Cattle : 10 days.
Sheep : 8 days.
Vial of 50 and 100 ml.
General principles of treatment
Acne can be effectively treated, although response may sometimes be slow.
Where possible, avoid excessively humid conditions such as a sauna, working in an unventilated kitchen or tropical vacations (but ultraviolet light helps).
Try not to apply irritant oils or cosmetics to the affected skin.
Abrasive skin treatments can aggravate both comedones and inflammatory lesions.
Try not to scratch or pick the spots
No relationship between particular foods and acne has been proven.
Management of mild acne
Most patients with mild acne can be treated with topical agents (gels, solutions and lotions) that can be obtained over-the-counter in New Zealand without prescription. Most people just use topical agents for facial skin as they can be difficult to apply to one’s back. Extra vitamins and minerals have not been proved to help.
Wash affected areas twice daily with a mild cleanser and water or an antiseptic wash.
Acne products should be applied to all areas affected by acne, rather than just put on individual spots.
A thin smear should only be applied to dry clean skin at nighttime.
Acne products may work better if applied in the morning as well.
They often cause dryness particularly in the first 2-4 weeks of use. This is partly how they work. The skin usually adjusts to this.
Apply an oil-free moisturizer only if the affected skin is obviously peeling.
Avoid applying oily cosmetics such as foundation or sunscreen.
It may take several weeks or even months to see convincing improvement.
Discontinue using product if severe irritation results. See your doctor for advice.
Suitable topical agents for mild acne that can be obtained without prescription include:
Antiseptic washes (Acnederm wash™, Benzac™ AC Wash, Dalacin™ T Prewash, Oxy™ Daily Skin Wash)
Mild salicylic acid preparations to exfoliate and unplug the follicles (Neutrogena® Oil-free Acne Wash and many others)
Benzoyl peroxide cream / lotion / gel (PanOxyl™ Acne Gel, Brevoxyl™ Cream, Oxy-10™, Clearasil™ Ultra Acne Cream, Benzac AC Gel)
Azelaic acid (Skinoren™ cream, Acnederm™ medicated lotion)
Hydrogen peroxide in stabilised cream (Crystacide®)
Tea tree oil products
Topical agents for mild acne which require prescription include:
Antibiotics, such as clindamycin solution (Topicil™) or erythromycin solution (Stiemycin™) and gel (Eryacne™) are best used with benzoyl peroxide or azelaic acid to reduce the chance of antibiotic resistance.
Retinoids i.e. tretinoin (Retin-A™), isotretinoin (Isotrex™), adapalene (Differin™).
Blue light acne treatment is a new procedure recently found to be safe and helpful for mild to moderate acne.
See your doctor or dermatologist for advice if your pimples fail to clear up within six weeks or you have severe acne.
Management of moderately severe acne
Treatment for moderately severe acne usually includes topical agents. In addition, a doctor or dermatologist may prescribe an oral medication, usually for at least six months.
Suitable oral medications include:
Antibiotics such as tetracycline, minocycline, doxycycline or erythromycin
In females, oestrogens and antiandrogens such as Diane 35™/Estelle 35™ or spironolactone
Some patients are helped by nonsteroidal anti-inflammatory agents such as ibuprofen or naproxen
For resistant or persistent acne, oral isotretinoin may be more suitable
See your doctor or dermatologist for advice if your skin problem fails to improve within three months or you have severe acne.
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