A sterile solution for injection containing:
Dexamethasone Sodium Phosphate 2mg/ml
Benzyl Alcohol as preservative 20mg/ml
Dexamethasone is a synthetic corticosteroid with a potent anti-inflammatory action: Colvasone can be used for:
1.Intravenous therapy in cases where emergency treatment is indicated, particularly shock and circulatory collapse, fogfever, acute mastitis and burns.
2.Acetonaemia (Ketosis) in cattle: Colvasone has a marked glucogenic action.
3.Inflammatory conditions in all species: Colvasone will suppress inflammation and is indicated in the treatment of arthritis, laminitis excluding horses, dermititis, etc.
Dosage and Administration:
By intravenous or intramuscular injection.
Normal aseptic precautions should be observed.
Horses and cattle: 1ml per 25kg bodyweight
Dogs and cats: 1ml per 10kg bodyweight
Animal Weight kg Dose
Horses 500kg 20ml
Cattle 400kg 16ml
Dogs 10kg 1ml
Cats 5kg 0.5ml
To ensure accuracy of dosing, a suitably graduated syringe should be used when treating small animals.
Cattle must not be slaughted for human consumption during treatment. Cattle may be slaughtered for human consumption only after 21 days from the last treatment. Milk must not be taken for human consumption during treatment. Milk for human consumption may be taken from cows only from 84 hours after the last treatment.
Do not use in horses intended for human consumption.
Contraindications, Warnings, etc:
Care should be taken to avoid accidental selfinjection. Systemic corticosteroid therapy is generally contraindicated in patients with renal disease and diabetes mellitus. Anti-inflammatory corticosteroids, such as dexamethasone, are known to exert a wide range of side effects. Whilst single high doses are generally well tolerated, they may induce severe sideeffects in long term use and when esterspossessing a long duration of action are administered. Dosage in medium to long term use should therefore generally be kept to the minimum necessary to control symptoms.
Steroids themselves, during treatment, may cause Cushingoid symptoms involving significant alteration of fat, carbohydrate, protein and mineral metabolism, e.g. redistribution of body fat, muscle weakness and wastage and osteoporosis may result.
During therapy effective doses suppress the HypothalamoPituitrealAdrenal axis. Following cessation of treatment, symptoms of adrenal insufficiency extending to adrenocorticol atrophy can arise and this may render the animal unable to deal adequately with stressful situations. Consideration should therefore be given to means of minimising problems of adrenal insufficiency following the withdrawal of treatment, e.g. a gradual reduction of dosage (for further discussion see standard texts).
Systemically acting corticosteroids may cause polyuria, polydipsia and polyphagia, particularly during the early stages of therapy. Some corticosteroids may cause sodium and water retention and hypokalaemia in long term use.
Systemic corticosteroids have caused deposition of calciumin the skin (calcinosis cutis) .
Corticosteroids are not recommended for use in pregnant animals. Administration in early pregnancy is known to have caused foetal abnormalities in laboratory animals. Administration in late pregnancy may cause early parturition or abortion. Corticosteroids may delay wound healing and the immunosuppressant actions may weaken resistance to or exacerbate existing infections. In the presence of bacterial infection, antibacterial drug cover is usually required when steroids are used. In the presence of viral infections, steroids may worsen or hasten the progress of the disease.
Combiclav Suspension for Injection64Gastrointestinal ulceration has been reported in animals treated with corticosteroids and g.i.t. ulceration may be exacerbated by steroids in patients given nonsteroidal antiinflammatory drugs and in corticosteroidtreated animals with spinal cord trauma. Steroids may cause enlargement of the liver hepatomegaly with increased serum hepatic enzymes. Use of the product in horses could induce laminitis and therefore careful observations during treatment should be made.
During a course of treatment the situation should be reviewed frequently by close veterinary supervision.
Do not store above 25�C.Once a vial has been broached, the contents should be used within 28 days. Discard any unused material. Dispose of any unused product and empty containers in accordance with guidance from your local waste regulation authority.
Wash hands after use.
To be supplied only on Veterinary Prescription.
Multidose vials of 50ml.
For Animal Treatment Only
Keep out of reach and sight of Children
How To Oil Pull
The most effective oil pulling is done by placing around a tablespoon of cold pressed organic sesame oil into the mouth and swishing the oil around the mouth for approximately 10-15 minutes and then spitting it out.
Other oils such as extra virgin cold pressed coconut, sunflower and olive oil have been used, although sesame oil is considered one of the best oils for this practice. I recommend alternating oils every couple of days to get the full benefit. Putting high quality organic oils into the mouth has a multi-effect outcome.
First, the oils mix with the saliva, turning it into a thin, white liquid. Lipids in the oils begin to pull out toxins from the saliva. As the oil is swished around the mouth, teeth, gums and tongue, the oil continues to absorb toxins, and usually ends up turning thick and viscous and white. Once the oil has reached this consistency, it is spit out before the toxins are reabsorbed.
What Does Oil Pulling Do?
Multiple scientific studies show the efficacy of oil pulling therapy. One study shows that oil pulling with sesame oil can boost overall oral health. Specifically, using sesame oil as an oral health agent helps to reduce the amount of S. mutans (germ) count in both teeth plaque and mouth saliva. Scientists believe that the lipids in the oil both pull out bacteria, as well as stop bacterial from sticking to the walls of the oral cavity.
Oil pulling may also increase saponification in the mouth, creating a soapy environment that cleanses the mouth as vegetable fat is an emulsifier by nature. Most interesting is perhaps the ability of oil to cleanse out harmful bacteria, as well as reduce fungal overgrowth. These oils also possibly help in cellular restructuring, and are related to the proper functioning of the lymph nodes and other internal organs.
Other possible benefits of oil pulling for oral health include:
Overall strengthening of the teeth and gums and jaws
Prevention of diseases of the gums and mouth, such as cavities and gingivitis
Prevention for bad breath
Potential holistic remedy for bleeding gums
Prevention of dryness of the lips, mouth and throat
Possible holistic treatment for TMJ and general soreness in the jaw area
Benefits Beyond the Mouth?
Ancient Ayurvedic health practitioners believed that oil pulling could reduce more than just diseases of the mouth and throat. Today, many holistic practitioners tout its use for a variety of health concerns.
It is believed that these oils help the lymphatic system of the body as harmful bacteria are removed and beneficial microflora are given with a healthy environment to flourish. Because of this holistic perspective, oil pulling has been used as a preventative health measure for many other conditions.
Other possible benefits of oil pulling for overall health include:
Migraine headache relief
Correcting hormone imbalances
Reducing inflammation of arthritis
May help with gastro-enteritis
Aids in the reduction of eczema
May reduce symptoms of bronchitis
Helps support normal kidney function
May help reduce sinus congestion
Some people report improved vision
Helps reduce insomnia
Reduced hangover after alcohol consumption
Aids in reducing pain
Reduces the symptoms of allergies
Helps detoxify the body of harmful metals and organisms
Scientific Studies on Sesame Oil and Oil Pulling
Sesame oil is particularly high in the antioxidantssesamol, sesamin, and sesamolin. It also holds a high concentration of Vitamin E and polyunsaturated fatty acids. These antioxidants have been found to stop the absorption of negative forms of cholesterol in the liver. Multiple studies have shown the antibacterial capacities of sesame oil. These studies support the use of oil pulling in the prevention of dental cavities and gingivitis.
A 2007 study looking into the effect of oil pulling (with sunflower oil) on plaque and gingivitis on oral soft and hard tissues. Results found that after 45 days of oil pulling, subjects showed a statistically significant reduction in gingivitis.
Another study, conducted in 2008 found a “remarkable reduction in the total count of bacteria” in the mouth, and an overall marked reduction in susceptibility dental cavities. The antibacterial activity of sesame oil was also studied and found to have an effect on the Streptococcus mutans in the mouth.
In fact, these studies showed an overall reduction of bacteria from 10 to 33.4% in participants, and after 40 days of oil-pulling, participants were found to show 20% in average reduction in oral bacteria. Moreover, half of all participants in this case study showed a drastic reduction in susceptibility to dental caries.