It is a reddish injectable solution.
Generic name: Nitroxynil Injection 34%.
Brand Name: Buxynil 34
Mol Weight:290.02 CAS No:1689-89-0
Buxynil 34 is nitrate derivative from benzene compounds and presents a flukicide effect and is commonly used and the one with best spectrum from all the nitrate derivative trematocides. The mechanism of action corresponds to a respiratory metabolism interference of the helminth, blocking the energy production by mitochondrial oxidative phosphorylation. Buxynil 34 impedes to use the oxide-reduction reactions for adenosine triphosphate (ATP) production. After the use of all its energetic reserves the parasites die due to starvation.
Buxynil 34 also causes the scolex detachment of the intestinal mucosa and the proximal proglottid of the cestode. Studies realized with Buxynil 34 demonstrates that effective blood levels are reached after 5 hours of the drug's administration and with maximum peaks after 12 hours, with an activity threshold during 30 days that maximizes its antiparasitic action.
There can be noted that it is associated strongly to the plasmatic proteins favoring its distribution to the tissues and its slow elimination of the organism. The biotransformation occurs in the gastrointestinal tract and liver. The Buxynil 34 and its metabolites are eliminated by faeces through the bile route.
It is suggested that it acts inhibiting the oxidative phosphorylation. It is possible to confirm its effects over Fasciola gigantica in laboratory conditions, after adding 20 mg/ml in vitro, which induces the immediate stop of the muscular contractions, making think that acts as neuromuscular blocker, due to this the parasite dies paralyzed and with energy deficiency.
Buxynil 34 is used by parenteral route because in the rumen would suffer an efficiency reduction; the maximum plasmatic levels are acquired between 30 and 60 minutes and the mean life is 8 days; the excretion occurs through urine during 30 days approximately.
Buxynil 34 is indicated for control of Fasciolosis (larval and adult stage) caused by Fasciola hepatica and F. gigantica; gastrointestinal parasitism caused by Haemonchus spp., Bunostomum spp., Oesophagostomum spp., Oestrus spp. in cattle, sheep, goats and camel, as well as Ancylostoma spp. and Uncinaria spp.in dogs.
Buxynil 34 is developed and tested for its use in cattle, sheep, goats, camel and dogs.
DOSAGE AND ADMINISTRATION
Subcutaneous route only.
The Standard dosage is 10mg per 1 kg bodyweight (=1.5 ml of Buxynil 34/50kg b.w.).
Cattle, Sheep, Goat, Camel and Dogs:
1ml every 50kg of body weight against Fasciola hepatica and F.gigantica.
1.5 ml every 50 kg of body weight against Haemochus contortus, Oesophagostomum spp., Bunostomum spp., Ancylostoma caninum and Uncinatia spp.
2.0 ml every 50 kg of body weight in cases of acute severe Fasciolosis and Oestrosis in sheep (Oestrus ovis).
A slight swelling may appear at the site of inoculation, which will disappear in a few days.
PRECAUTIONS AND WARNINGS
Only dose cows on dry period.
Do not mix in the same syringe or container with any other substance different to the product.
The containers and any residue of product should be eliminated in a safe way (burial or incineration).
The use on other species than authorized is not recommended.
It can be used at any stage of pregnancy (however, in the last third, the product must be managed very carefully under professional supervision); it does not affect fertility, gestation nor fetus formation, and it does not affect the reproductive performance of stallions.
In case of intoxication, keep the patient in a cold place and administer dextrose by endovenous route.
In case of ingestion, wash mouth and request help to the veterinarian.
Be careful of auto inject accidentally. Seek medical attention in case of accidental injection.
Meat: 30 days. Milk: 5 days. Dose only cows on dry period.
Buxynil 34 is available in bottle of 100ml
Store in a cool, dry and dark place.
Genexa is a brand of OTC homeopathic medicines. Their effective, potent, certified organic and non-GMO remedies are manufactured in an environmentally friendly and sustainable method. All Genexa organic medicines are produced in compliance with FDA Good Manufacturing Practices (GMPs) and portions of their net profits are donated to charities that focus on critical pediatric services and children’s health.
Learn more about Genexa on our blog: https://blog.professionalsupplementcenter.com/featured-brand-genexa/#.V8h4IigrKHs
Top rated products from Genexa include:
Allergy-D – This formula addresses symptoms associated with seasonal allergies, such as irritated eyes, sinus and nasal congestion, sneezing, runny nose, or itchy throat. Children’s formula also available. Product UPC 857630006052 Link: https://www.professionalsupplementcenter.com/Allergy-D-for-Adults-by-Genexa.htm
Jet Lag Rx – Make the most of your travel time with this proprietary formula designed to prevent or address symptoms such as fatigue, sleeplessness, early waking, sluggishness and nausea. Product UPC 857630006014 Link: https://www.professionalsupplementcenter.com/Jet-Lag-Rx-by-Genexa.htm
Calming Aid for Children – This safe and effective formula helps children to feel more relaxed and calm and addresses symptoms associated with stress, restlessness, oversensitivity, inability to concentrate, sleeplessness and nervousness. Product UPC 857630006106 Link: https://www.professionalsupplementcenter.com/Calming-Aid-for-Children-by-Genexa.htm
Sleepology – This non-habit forming sleep aid is designed with 9 leading homeopathic remedies to address sleeplessness, restless sleep, frequent waking and inability to fall asleep. Product UPC 857630006090 Link: https://www.professionalsupplementcenter.com/Sleepology-by-Genexa.htm
Receive SPECIAL OFFERS When you SIGN UP for our Good Health News Letter: https://www.professionalsupplementcenter.com/ThankYouSignup.aspx
Check out our Daily Deals on High Quality Vitamins and Supplements here: https://www.professionalsupplementcenter.com/Daily-Deals.htm
Our resident nurse specializes in assessing, developing, and coaching to optimize one’s health with the proper use of high quality vitamins and supplements. Take advantage of our FREE Ask The Nurse feature on our website: https://www.professionalsupplementcenter.com/AskTheNurse.aspx
Phone (888) 245-5000