7 Years Factory Nitroxynil Injection 34%_100ml_Buxynil Poland Manufacturers

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  • Price: FOB Shanghai: Discuss in Person
  • MOQ(50ml,100ml(g)): 5000 Bottle/Bag
  • MOQ(250ml,500ml(g)): 2000 Bottle/Bag
  • MOQ(5ml,10ml): 30000 Bottle/Vial
  • Shipment Port: Shanghai, Guangzhou, Chongqing, Yiwu
  • Payment Terms: T/T, L/C
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    7 Years Factory Nitroxynil Injection 34%_100ml_Buxynil Poland Manufacturers Detail:

    COMPOSITION

    Each 1ml contains Nitroxynil 340mg with Excipients q.s.to 1ml.

    DESCRIPTION

    It is a reddish injectable solution.

    Generic name: Nitroxynil Injection 34%.

    Brand Name: Buxynil 34

    Chemical Name:

    Lodine-2-hydroxi-4-nitro-5-benzonitrile (cyano4-iodine,2,nitro-6phenol)

    Chemical Structure:

    Mol Weight:290.02                      CAS No:1689-89-0

    CLNICAL PHARMACOLOGY

    Parmacodynamics:

    Buxynil 34 is nitrate derivative from benzene compounds and presents a flukicide effect and is commonly used and the one with best spectrum from all the nitrate derivative trematocides. The mechanism of action corresponds to a respiratory metabolism interference of the helminth, blocking the energy production by mitochondrial oxidative phosphorylation. Buxynil 34 impedes to use the oxide-reduction reactions for adenosine triphosphate (ATP) production. After the use of all its energetic reserves the parasites die due to starvation.

    Buxynil 34 also causes the scolex detachment of the intestinal mucosa and the proximal proglottid of the cestode. Studies realized with Buxynil 34 demonstrates that effective blood levels are reached after 5 hours of the drug's administration and with maximum peaks after 12 hours, with an activity threshold during 30 days that maximizes its antiparasitic action.

    Pharmacokinetics:

    There can be noted that it is associated strongly to the plasmatic proteins favoring its distribution to the tissues and its slow elimination of the organism. The biotransformation occurs in the gastrointestinal tract and liver. The Buxynil 34 and its metabolites are eliminated by faeces through the bile route.

    It is suggested that it acts inhibiting the oxidative phosphorylation. It is possible to confirm its effects over Fasciola gigantica in laboratory conditions, after adding 20 mg/ml in vitro, which induces the immediate stop of the muscular contractions, making think that acts as neuromuscular blocker, due to this the parasite dies paralyzed and with energy deficiency.

    Buxynil 34  is used by parenteral route because in the rumen would suffer an efficiency reduction; the maximum plasmatic levels are acquired between 30 and 60 minutes and the mean life is 8 days; the excretion occurs through urine during 30 days approximately.

    INDICATIONS

    Buxynil 34 is indicated for control of  Fasciolosis (larval and adult stage) caused by Fasciola hepatica and F. gigantica; gastrointestinal parasitism caused by Haemonchus spp., Bunostomum spp., Oesophagostomum spp., Oestrus spp. in cattle, sheep, goats and camel, as well as Ancylostoma spp. and Uncinaria spp.in dogs.

    TARGET ANIMAL

    Buxynil 34 is developed and tested for its use in cattle, sheep, goats, camel and dogs.

    DOSAGE AND ADMINISTRATION

    Subcutaneous route only.

    The Standard dosage is 10mg per 1 kg bodyweight (=1.5 ml of Buxynil 34/50kg b.w.).

    Cattle, Sheep, Goat, Camel and Dogs:

    1ml every 50kg of body weight against Fasciola hepatica and F.gigantica.

    1.5 ml every 50 kg of body weight against Haemochus contortus, Oesophagostomum spp., Bunostomum spp., Ancylostoma caninum and Uncinatia spp.

    2.0 ml every 50 kg of body weight in cases of acute severe Fasciolosis and Oestrosis in sheep (Oestrus ovis).

    SIDE EFFECTS

    A slight swelling may appear at the site of inoculation, which will disappear in a few days.

    PRECAUTIONS AND WARNINGS

    Only dose cows on dry period.

    Do not mix in the same syringe or container with any other substance different to the product.

    The containers and any residue of product should be eliminated in a safe way (burial or incineration).

    The use on other species than authorized is not recommended.

    It can be used at any stage of pregnancy (however, in the last third, the product must be managed very carefully under professional supervision); it does not affect fertility, gestation nor fetus formation, and it does not affect the reproductive performance of stallions.

    In case of intoxication, keep the patient in a cold place and administer dextrose by endovenous route.

    In case of ingestion, wash mouth and request help to the veterinarian.

    Be careful of auto inject accidentally. Seek medical attention in case of accidental injection.

    WITHDRAWAL PERIOD

    Meat: 30 days. Milk: 5 days. Dose only cows on dry period.

    VALIDITY

    2 years

    PACKING

    Buxynil 34  is available in bottle of 100ml

    STORAGE

    Store in a cool, dry and dark place.


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    Couve – Brassica oleracea var. acephala

    Um estudo americano demonstra que a couve é um alimento rico em minerais. Os resultados deste estudo mostram que uma única dose de 100 g de couve fresca pode fornecer uma porcentagem significativa da ingestão diária recomendada de micronutrientes minerais (188-873 mg K, 35-300 mg Ca; 20-100 mg Mg), além de ser fonte de carboidratos de absorção lenta e ter baixo valor calórico. Além disso a couve é rica em vitamina A, vitaminas do complexo B, vitamina C e K.

    Por estas informações, temos que a couve é uma excelente opção na prevenção da osteoporose, dada sua concentração de minerais e das vitaminas A e K, que são importantíssimas na saúde dos ossos.

    Como protetora estomacal, o extrato de couve foi testado em dois estudos, um realizado em Santa Catarina e o outro no Paquistão e em ambos verificou-se que ela é capaz de aumentar a produção de muco na parede do estômago e reduzir a acidez estomacal, auxiliando no combate à gastrite e úlcera. Ainda um estudo realizado no Brasil demonstrou que o suco de couve tem ação protetora contra o refluxo similar à do Omeprazol, protegendo o estomago e prevenindo problemas como gastrite, úlcera e câncer estomacal.

    Um estudo coreano e um estudo japonês demonstraram que as folhas de couve tem ação hipoglicemiante, contribuindo no tratamento da diabetes tipo 2.

    Sobre a pressão arterial um estudo coreano demonstrou que o suco de couve administrado diariamente por 28 dias a pacientes hipertensos, além de auxiliar significativamente no controle da pressão arterial, ainda controlou os níveis de açúcar e melhorou o perfil de colesterol no organismo.
    Contra problemas cardiovasculares, um estudo turco demonstrou que o suco de couve reduz significativamente a oxidação do colesterol LDL, evitando por exemplo a arteriosclerose.

    Combatendo bactérias, o extrato da couve mostrou boa ação, evitando o desenvolvimento de alguns tipos de bactérias.

    Como protetora do DNA, evitando degradação do material genético e mutações que podem vir a dar origem ao câncer, a couve foi testada pela UNESP e verificou-se que mesmo com a indução da mutação genética, o DNA das células testadas se manteve intacto sob ação da couve.

    Como antioxidante, um estudo polonês determinou que por sua alta concentração de Vitamina C e beta-caroteno, a coute apresenta excelente atividade antioxidante, o que justifica suas capacidades protetoras do DNA e anticancerígenas.

    No combate ao câncer, um estudo realizado entre a Inglaterra e Noruega demonstrou que o suco da couve tem uma potente ação antiproliferativa contra células de câncer colorretal.

    https://www.sciencedirect.com/science/article/pii/S0378874111007173

    https://www.sciencedirect.com/science/article/pii/S0889157516301132

    https://www.sciencedirect.com/science/article/pii/S0378874112005259

    https://www.sciencedirect.com/science/article/pii/S0308814607006826

    https://www.sciencedirect.com/science/article/pii/0378874189900883

    https://ocean.kisti.re.kr/downfile/volume/kshs/OOHHBV/2010/v28n5/OOHHBV_2010_v28n5_850.pdf

    https://synapse.koreamed.org/Synapse/Data/PDFData/0161NRP/nrp-9-49.pdf

    https://www.jstage.jst.go.jp/article/jtm/24/6/24_6_187/_pdf

    https://imsear.li.mahidol.ac.th/handle/123456789/135341

    https://pubs.acs.org/doi/abs/10.1021/jf300875f

    https://www.food.actapol.net/volume11/issue3/abstract-3.html

    https://thritajournal.com/?page=article&article_id=34363

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