Synonyms: Identification numbers
CAS number: 70288-86-7 (mixture)
Other numbers: 70161-11-4 (component B1a) 70209-81 (component B1b)
Brand names, Trade names: BULIVER, SANIVER, VIMIVER
Each ml. contains ivermectin 10 mg.
Parasitic diseases are common in animals. Parasites can affect the skin, ears, stomach and intestines, and the internal organs including the heart, lungs and liver. Several drugs have been developed to kill or prevent parasites such as fleas, ticks, mites and worms. Ivermectin and related drugs are among the most effective of these.
Ivermectin is a parasite control drug. Ivermectin causes neurologic damage to the parasite, resulting in paralysis and death. Ivermectin has been used to prevent parasite infections, as with heartworm prevention, and to treat infections, as with ear mites.
Ivermectin is a prescription drug and can only be obtained from a veterinarian or by prescription from a veterinarian.
The injection is mainly applied to treat domestic animal’s diseases of gastrointestinal nematodes, hypoderma bovis, hypoderma lineatum, sheep nose bot, psoroptes ovis, sarcoptes scabiei var. Suis,sarcoptes ovis, fasciola(Liver Fluke), oestrus spp and the like.
Cattle: Ostertagia ostertagi (including inhibited o. ostertagi), o. lyrata, haemonchus placei, trichostrongylus axei, t. colubriformis, cooperia oncophora, c. punctata, c. pectinata, bunostomum phlebotomum, nematodirus helvetianus (adults only), n. spathiger (adults only), oesophagostomum radiatum, dictyocaulus viviparus, fasciola hepatica (adults only), hypoderma bovis, h. lineatum, linognathus vituli, haematopinus eurysternus, solenopotes capillatus, psoroptes ovis (syn. p. communis var. bovis), sarcoptes scabiei var. bovis. Sheep: Oestrus ovis, sarcoptes scabiei, psoregates var ovis, trichostrongylus axei, haemonchus sps., ostertagia sps., trichostrongylus sps., nematodirus sps., cooperia sps., bunostomum sps., strongyloides sps., oesophagastomum sps., chabertia sps., trichuris sps., dictyocaulus sps. Dogs: Sarcoptes scabiei, otodectes cynotis, toxascaris leonina, toxocara caninum / cati, uncinaria stenocephala, ancylostoma caninum, trichuris vulpis,dirifilaria (larval stages)
Usage and administration:
Cattle: 1.0 ml/50 kg body weight.
Sheep: 0.5 ml/25 kg body weight.
Dogs: 0.5 ml /25 kg body weight.
Medication should never be administered without first consulting your veterinarian. The dose for ivermectin varies from species to species and also depends on the intent of treatment. General dosing guidelines follow.
For dogs: Dose is 0.0015 to 0.003 mg per pound (0.003 to 0.006 mg/kg) once a month for heartworm prevention; 0.15 mg per pound (0.3 mg/kg) once, then repeat in 14 days for skin parasites; and 0.1 mg per pound (0.2 mg/kg) once for gastrointestinal parasites.
For cats: Dose is 0.012 mg per pound (0.024 mg/kg) once monthly for heartworm prevention.
The duration of administration depends on the condition being treated, response to the medication and the development of any adverse effects. Be certain to complete the prescription unless specifically directed by your veterinarian. Even if your pet feels better, the entire treatment plan should be completed to prevent relapse or prevent the development of resistance.
Side effect and contraindication:
While generally safe and effective when prescribed by a veterinarian, ivermectin can cause side effects in some animals. Ivermectin should not be used in animals with known hypersensitivity or allergy to the drug. Ivermectin should be used with caution in collie breeds or collie mixed breeds due to potential toxic effects. This is particularly true when using higher doses. Ivermectin should not be used in dogs that are positive for heartworm disease except under strict supervision of a veterinarian. Prior to starting a heartworm prevention containing ivermectin, the dog should be tested for heartworms. Ivermectin generally should be avoided in dogs less than 6 weeks of age. Ivermectin is relatively safe, but overdoses can occur if massive amounts are given or if the drug is given to heartworm positive dogs. Signs of overdose, including stumbling, tremors, blindness, disorientation or weakness, generally occur within 12 hours of overdose.
In heartworm positive dogs, supportive treatment for shock may be required. Ivermectin should be used with caution at high doses, a drug used to treat or prevent flea infestations.
The withdrawal time of 49 days has been established for ivermectin and clorsulon in cattle and sheep for slaughter. A withdrawal period for milk has not been established.
Keep this and all drugs out of the reach of children.
Storage and expired time：
Put in cool, dry and dark place.
How To Oil Pull
The most effective oil pulling is done by placing around a tablespoon of cold pressed organic sesame oil into the mouth and swishing the oil around the mouth for approximately 10-15 minutes and then spitting it out.
Other oils such as extra virgin cold pressed coconut, sunflower and olive oil have been used, although sesame oil is considered one of the best oils for this practice. I recommend alternating oils every couple of days to get the full benefit. Putting high quality organic oils into the mouth has a multi-effect outcome.
First, the oils mix with the saliva, turning it into a thin, white liquid. Lipids in the oils begin to pull out toxins from the saliva. As the oil is swished around the mouth, teeth, gums and tongue, the oil continues to absorb toxins, and usually ends up turning thick and viscous and white. Once the oil has reached this consistency, it is spit out before the toxins are reabsorbed.
What Does Oil Pulling Do?
Multiple scientific studies show the efficacy of oil pulling therapy. One study shows that oil pulling with sesame oil can boost overall oral health. Specifically, using sesame oil as an oral health agent helps to reduce the amount of S. mutans (germ) count in both teeth plaque and mouth saliva. Scientists believe that the lipids in the oil both pull out bacteria, as well as stop bacterial from sticking to the walls of the oral cavity.
Oil pulling may also increase saponification in the mouth, creating a soapy environment that cleanses the mouth as vegetable fat is an emulsifier by nature. Most interesting is perhaps the ability of oil to cleanse out harmful bacteria, as well as reduce fungal overgrowth. These oils also possibly help in cellular restructuring, and are related to the proper functioning of the lymph nodes and other internal organs.
Other possible benefits of oil pulling for oral health include:
Overall strengthening of the teeth and gums and jaws
Prevention of diseases of the gums and mouth, such as cavities and gingivitis
Prevention for bad breath
Potential holistic remedy for bleeding gums
Prevention of dryness of the lips, mouth and throat
Possible holistic treatment for TMJ and general soreness in the jaw area
Benefits Beyond the Mouth?
Ancient Ayurvedic health practitioners believed that oil pulling could reduce more than just diseases of the mouth and throat. Today, many holistic practitioners tout its use for a variety of health concerns.
It is believed that these oils help the lymphatic system of the body as harmful bacteria are removed and beneficial microflora are given with a healthy environment to flourish. Because of this holistic perspective, oil pulling has been used as a preventative health measure for many other conditions.
Other possible benefits of oil pulling for overall health include:
Migraine headache relief
Correcting hormone imbalances
Reducing inflammation of arthritis
May help with gastro-enteritis
Aids in the reduction of eczema
May reduce symptoms of bronchitis
Helps support normal kidney function
May help reduce sinus congestion
Some people report improved vision
Helps reduce insomnia
Reduced hangover after alcohol consumption
Aids in reducing pain
Reduces the symptoms of allergies
Helps detoxify the body of harmful metals and organisms
Scientific Studies on Sesame Oil and Oil Pulling
Sesame oil is particularly high in the antioxidantssesamol, sesamin, and sesamolin. It also holds a high concentration of Vitamin E and polyunsaturated fatty acids. These antioxidants have been found to stop the absorption of negative forms of cholesterol in the liver. Multiple studies have shown the antibacterial capacities of sesame oil. These studies support the use of oil pulling in the prevention of dental cavities and gingivitis.
A 2007 study looking into the effect of oil pulling (with sunflower oil) on plaque and gingivitis on oral soft and hard tissues. Results found that after 45 days of oil pulling, subjects showed a statistically significant reduction in gingivitis.
Another study, conducted in 2008 found a “remarkable reduction in the total count of bacteria” in the mouth, and an overall marked reduction in susceptibility dental cavities. The antibacterial activity of sesame oil was also studied and found to have an effect on the Streptococcus mutans in the mouth.
In fact, these studies showed an overall reduction of bacteria from 10 to 33.4% in participants, and after 40 days of oil-pulling, participants were found to show 20% in average reduction in oral bacteria. Moreover, half of all participants in this case study showed a drastic reduction in susceptibility to dental caries.