Each ml contains oxytetracycline 50 mg.
Buloxy 5% is a wide spectrum bacteriostatic antibiotic. It acts on gram-positive and gram-negative micro-organisms. It is particularly sensitive to streptococci, clostridia, E.coli, shigellae, brucellae, salmonellae, leptospirae etc. In addition, it is effective against some mycoplasmas, rickettsiae, chlamydiae, some protozoa andlarge viruses.
After administration of therapeutic dose of Fangtongoxy 5%, a high level of oxytetracycline in blood is achieved within half an hour to 4 hours.
Treatment of diseases caused by oxytetracycline-susceptible organisms in cattle, sheep and goats. Diseases including pneumonia and shipping fever complex associated with Pasteurella spp and haemophilus spp, infectious bovine kerato-conjunctivitis ( pinkeye ) caused by moraxella bovis, foot rot and diphtheria caused by fusobacterium necrophorum, bacterial enteritis ( scours) caused by escherichia coli, wooden tongue caused by actinobacillus lignierisii; leptospirosis caused by leptospira pomoma; wound infections and acute metritis caused by strains of staphylocci and streptococci organisms sensitive to oxytetracycline.
For cattle: Bronchopneumonia and other respiratory infections, infections of the gastrointestinal tract, metritis, mastitis, septicaemia, puerperal infections, secondary bacterrial infections primarily caused by viruses, etc.
For sheep and goats: Infections of respiratory, urogenital, gastrointestinal tract and hooves, mastitis, infected wounds,etc.
DOSAGE AND ADMINISTRATION:
Administer by intramuscular injection. The dose of the active principle oxytetracycline amounts to 10 mg/kg bodyweight of the animal. Administer for 3 – 5 days depending on the type and severity of the infection. The administration is carried out in the following volume:
Cattle 2ml / 10 kg bodyweight
Calves 2 ml / 10 kg bodyweight
Sheep and goats 2 ml / 10 kg bodyweight
Pigs 2 ml / 10 kg bodyweight
Buloxy 5% is not intended for cats, dogs and horses. It should not be given to animals in late pregnancy, animals with severe damages of liver and kidneys and to animals oversensitive to oxytetraycline.
SIDE – EFFECTS:
Sometimes a temporary swelling on the injection site occurs.
From last treatment, within 21 days for meat and edible tissues and within 7 days for milk.
A maximum of 20 ml may be injected at any one site for cattle, and 5 ml maximum for sheep and goats.
If total volume exceeds the above mentioned quantity, it should be divided and injected to more sites.
The drug must not be diluted.
In a cool dry place under 25℃, away from direct sunlight.
In a 100ml glass bottle.
See the official research here: https://www-che.syr.edu/faculty/doyle.html#insulin
Utilizing vitamin B12 to deliver proteins orally or to target metallo-probes/chemotherapeutics to tumor cells.
Hypothesis: The vitamin B12 uptake pathway can be adopted to deliver clinically relevant doses of peptides/proteins orally. Mammals have a highly efficient uptake and transport mechanism in the gastrointestinal tract (GIT) for the absorption and cellular uptake of the vitamin B12 molecule (~1350 Da). The proposed delivery system would take advantage of this natural intrinsic factor (IF) mediated uptake mechanism to overcome the two major hurdles to peptide delivery, namely GIT proteolysis and transcytoses of the enterocyte . Vitamin B12 first binds to haptocorrin, a salivary enzyme that can protect and transport B12 through the stomach and into the small intestine (see Figure 2). The B12 then binds to IF and proceeds down the small intestine where the complex binds to the IF receptor on the ileum wall. The IF-B12 receptor complex then undergoes endocytosis, releasing B12 into the blood serum where it is bound to transcobalamin II (TCII).
Doyle, R. P.; Petrus, A. K.; Allis, D. G.; Smith, R. P.; Fairchild, T. J. Exploring the Implications of Vitamin B12 Conjugation to Insulin on Insulin Receptor Binding. ChemMedChem 2009, 4, 421-426.