Synonyms: Identification numbers
CAS number: 70288-86-7 (mixture)
Other numbers: 70161-11-4 (component B1a) 70209-81 (component B1b)
Brand names, Trade names: BULIVER, SANIVER, VIMIVER
Each ml. contains ivermectin 10 mg.
Parasitic diseases are common in animals. Parasites can affect the skin, ears, stomach and intestines, and the internal organs including the heart, lungs and liver. Several drugs have been developed to kill or prevent parasites such as fleas, ticks, mites and worms. Ivermectin and related drugs are among the most effective of these.
Ivermectin is a parasite control drug. Ivermectin causes neurologic damage to the parasite, resulting in paralysis and death. Ivermectin has been used to prevent parasite infections, as with heartworm prevention, and to treat infections, as with ear mites.
Ivermectin is a prescription drug and can only be obtained from a veterinarian or by prescription from a veterinarian.
The injection is mainly applied to treat domestic animal’s diseases of gastrointestinal nematodes, hypoderma bovis, hypoderma lineatum, sheep nose bot, psoroptes ovis, sarcoptes scabiei var. Suis,sarcoptes ovis, fasciola(Liver Fluke), oestrus spp and the like.
Cattle: Ostertagia ostertagi (including inhibited o. ostertagi), o. lyrata, haemonchus placei, trichostrongylus axei, t. colubriformis, cooperia oncophora, c. punctata, c. pectinata, bunostomum phlebotomum, nematodirus helvetianus (adults only), n. spathiger (adults only), oesophagostomum radiatum, dictyocaulus viviparus, fasciola hepatica (adults only), hypoderma bovis, h. lineatum, linognathus vituli, haematopinus eurysternus, solenopotes capillatus, psoroptes ovis (syn. p. communis var. bovis), sarcoptes scabiei var. bovis. Sheep: Oestrus ovis, sarcoptes scabiei, psoregates var ovis, trichostrongylus axei, haemonchus sps., ostertagia sps., trichostrongylus sps., nematodirus sps., cooperia sps., bunostomum sps., strongyloides sps., oesophagastomum sps., chabertia sps., trichuris sps., dictyocaulus sps. Dogs: Sarcoptes scabiei, otodectes cynotis, toxascaris leonina, toxocara caninum / cati, uncinaria stenocephala, ancylostoma caninum, trichuris vulpis,dirifilaria (larval stages)
Usage and administration:
Cattle: 1.0 ml/50 kg body weight.
Sheep: 0.5 ml/25 kg body weight.
Dogs: 0.5 ml /25 kg body weight.
Medication should never be administered without first consulting your veterinarian. The dose for ivermectin varies from species to species and also depends on the intent of treatment. General dosing guidelines follow.
For dogs: Dose is 0.0015 to 0.003 mg per pound (0.003 to 0.006 mg/kg) once a month for heartworm prevention; 0.15 mg per pound (0.3 mg/kg) once, then repeat in 14 days for skin parasites; and 0.1 mg per pound (0.2 mg/kg) once for gastrointestinal parasites.
For cats: Dose is 0.012 mg per pound (0.024 mg/kg) once monthly for heartworm prevention.
The duration of administration depends on the condition being treated, response to the medication and the development of any adverse effects. Be certain to complete the prescription unless specifically directed by your veterinarian. Even if your pet feels better, the entire treatment plan should be completed to prevent relapse or prevent the development of resistance.
Side effect and contraindication:
While generally safe and effective when prescribed by a veterinarian, ivermectin can cause side effects in some animals. Ivermectin should not be used in animals with known hypersensitivity or allergy to the drug. Ivermectin should be used with caution in collie breeds or collie mixed breeds due to potential toxic effects. This is particularly true when using higher doses. Ivermectin should not be used in dogs that are positive for heartworm disease except under strict supervision of a veterinarian. Prior to starting a heartworm prevention containing ivermectin, the dog should be tested for heartworms. Ivermectin generally should be avoided in dogs less than 6 weeks of age. Ivermectin is relatively safe, but overdoses can occur if massive amounts are given or if the drug is given to heartworm positive dogs. Signs of overdose, including stumbling, tremors, blindness, disorientation or weakness, generally occur within 12 hours of overdose.
In heartworm positive dogs, supportive treatment for shock may be required. Ivermectin should be used with caution at high doses, a drug used to treat or prevent flea infestations.
The withdrawal time of 49 days has been established for ivermectin and clorsulon in cattle and sheep for slaughter. A withdrawal period for milk has not been established.
Keep this and all drugs out of the reach of children.
Storage and expired time：
Put in cool, dry and dark place.
It may be important for brain and nervous system functioning, but in the fight against acne, it could be beneficial to pass up on supplements of vitamin B12, according to a new study.
Don’t pass up on leafy green vegetables and other natural sources of vitamin B12 — it’s an essential nutrient — but taking a supplemental dose might not be practical if you want to get rid of acne.
“Vitamin B12 is essential to us,” said lead author Li Huiying in an interview with Relaxnews. “I hope people do not misinterpret the results of our study and think vitamin B12 is bad.”
You’ve probably heard of friendly gut bacteria that live in your intestines, keeping you healthy and the team of scientists from the University of California Los Angeles (UCLA) say it works a bit the same way on your face.
Yes, friendly facial bacteria can become unsettled by vitamin B12, leading to inflammation and eventually to pimples, according to their paper.
Vitamin B12 changes how genes behave in the facial microbiota — the term scientists use to describe the community of bacteria that lives on your face even after washing — leading to activity changes in these critters.
After coming up with that as a hypothesis, the scientists tested it by analyzing skin microbiota in healthy volunteers who took supplements of vitamin B12.
One of their 10 subjects developed acne within a week of vitamin B12 supplementation.
To further test their hypothesis, the scientists cultured acne-causing bacterium P. acnes and supplemented it with vitamin B12.
At this moment, they saw increased production of a group of organic compounds called porphyrins, which are well known to promote acne, according to the paper.
The idea that supplementing your diet with vitamin B12 brings about acne isn’t new; the scientists say in their paper that it’s been observed for sometime now, but they think their discovery of the molecular mechanism behind it could lead to new treatments.
“Some of the genes in the pathways described in our study potentially could be drug targets for new acne treatments,” said Huiying in an interview with Relaxnews.
The paper was published in the journal Science Translational Medicine.