Amoxicillinum trihydricum 17.221 g (corresponds to 15 g of amoxicillin).
Amoxicillin is a semi-synthetic derivative of penicillin, stable in acids, with a wide spectrum of effect against gram-positive and gram-negative bacteria.
Similar to other penicillins, the mechanism of its effect is based on a blockage of the synthesis of the cell wall in bacteria. The antibiotic is bound to a special binding protein, the synthesis of the cell wall is inhibited by the blockage of synthesis of peptidoglycan, and autolytic enzymes are activated in the cell wall resulting in wall lesions and cell death.
Antibacterial impact of amoxicillin includes a wide range of microbes such as Staphylococcus spp., Streptococcus spp. (this does not cause penicilliosis), Haemophilus spp., Corynebacterium spp., Brucella spp., Shigella spp., Fusiformis spp., Clostridia spp., Steptococcus faecalis, Salmonela spp., E. Coli, Proteum myrabilis, Proteus vulgaris (MIC 10 µg/ml). The strains with no sensitive reactions are those provoking penicilliosis such as Staphylococcus, Klepsiella, Pseudomonas and Proteus. Amoxicillin is absorbed quickly if administered i.m. and s.c. and maximum plasmatic levels are recorded (within 1 – 3 hours). Active values of the active substance persist in blood for 48 hours at least. Amoxicillin quickly penetrates into tissues and liquids. Particularly high concentration levels are observed in urine, bile, kidneys and livers. This preparation is transferred via placenta. The detected concentration values are higher compared to maternal blood levels. Amoxicillin can be eliminated in its unchanged form via kidneys. If Amixicillin is eliminated in milk during the lactation period, different animal species should be considered.
Therapy for diseases caused by germs sensitive to amoxicillin in cattle, sheep, pigs, and dogs.
These are, in particular, infections of the respiratory, gastrointestinal and urogenital systems, secondary bacterial complications of viral diseases, generalized septicemia, infections of the skin and wounds, omphalophlebitis, arthritis, abscesses, phlegmona, panaricia, metritis, mastitis, MMA-syndrome, swine fever and antibiotic protection for surgery. An examination concerning the sensitivity of the disease-causing agent to amoxicillin should be performed before the preparation is administered.
The preparation is not intended for animals whose microorganisms cause penicilliosis and those sensitive to penicillin.
Intramuscular and subcutaneous
10 mg of amoxicillin per kg of live weight per day or 1 ml per 15 kg of live weight per day.
Allergy to amoxicillin may occur rarely. A transient local reaction may occur in the place of application.
50 ml and 100 ml glass vials II HT closed with rubber piercing stoppers that are provided with aluminium strips.
100 ml, 250 ml and 500 ml plastic vials that are sealed with rubber piercing stoppers and aluminium strips.
The vials are inserted into cardboard boxes.
Size of packing:
Shake well before use. Do not mix with water solutions or other preparations. Use dry needles and syringes to prevent hydrolysis of the active substance. Do not apply more than 20 ml of the preparation in one location.
To be stored at temperatures of 15 – 25 oC.
Keep out of the reach of children.
Meat of cattle: 15 days; meat of pigs 42 days
Cow's milk: 72 hours.
24 months, 28 days after opening.
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